Endocrine Abstracts

Skeletal muscle is the principal site for insulin-stimulated glucose disposal but its ability to utilise glucose is diminished by insulin resistance associated with obesity and consequent elevations of free fatty acids (FFAs). Chronic sub-clinical inflammation, characterized by increased macrophage infiltration into obese adipose tissue is a hallmark of the insulin resistance syndrome. However, little is known about the potential role of muscle macrophages in mediating local e...

The increased incidence of type 2 diabetes mellitus (T2DM) among the aged is associated with an impaired skeletal structure and a higher prevalence for bone fractures. Besides, anti-diabetic therapies can also negatively affect bone mass. In this study, we tested the skeletal effects of chronic administration of two glucagon-like peptide receptor (GLP-1R) agonists and examined the expression of GLP-1R in bone tissue and cells. Twelve week-old female C57Bl/6N mice were ovariect...